HIP 2.0: Unveiling Our Scientific Plan to Decode and Model the Immune System

At the Human Immunome Project, 2023 has been a year of great transition and progress. In May, we welcomed new leadership with Hans Keirstead, PhD assuming the role of Chief Executive Officer. We engaged in a strategic planning process and refined our vision and mission. Together with leading immunologists, we developed an actionable scientific plan to generate immunological data at a scale not previously seen and build the first-ever AI models of the immune system with the aim to transform the future of global health.

This is HIP 2.0.

Our five-year strategy is designed to generate the world’s largest immunological dataset at a population level and to reflect the diversity of humanity and immune responses. We are employing a phased approach to collect the data, beginning with seven Pioneering Sites spread across the globe before scaling to 70-100 locations worldwide. The result will be the first AI models of the immune system, which enable scientists and health professionals to predict immune responses and individual health trajectories and offer personalized solutions to disease and common health challenges.

In the following five years, HIP will progress to building causal and mechanistic models of the immune system that will allow not only prediction but will provide quantitative, mechanistic information on how the immune system operates, transforming our ability to harness immunity to improve health and combat disease worldwide.

Alongside the scientific plan, we’re also introducing a new brand and website. Our new identity seeks to better reflect the complexity of the human immune system, the promise of AI models that can deepen our understanding of immunity, and the unique role that the Human Immunome Project plays in bringing the world together to achieve our transformative mission.

We invite you to explore our website and scientific plan and connect with us if you’re interested in partnering or supporting our work. Decoding and modeling the immune system is a global effort and we are dedicated to building a diverse, global network united behind the goal to improve health for all.

Stay up to date on HIP’s latest developments and progress by signing up for our quarterly newsletter!

Recent Posts

  • Advances in Systems Immunology and Machine Learning

    The convergence of advanced immune monitoring technologies and artificial intelligence, particularly machine learning, is creating unprecedented opportunities to decode human immunity.  In a comprehensive review published in the Annual Review of Immunology in April 2025, “Systems Human Immunology and AI: Immune Setpoint and Immune Health,” Yona Lei and HIP Co-Chief Science Officer John Tsang review and provide perspectives... Read More
  • First Diagnostic Immunome Accurately Predicts Disease

    “Disease diagnostics using machine learning of B cell and T cell receptor sequences”, published in Science on February 21, 2025, is a world-first demonstration of the scientific underpinnings of the Human Immunome Project. The study, led by Maxim Zaslavsky, Erin Craig, Anshul Kundaje, Scott Boyd and colleagues at Stanford and other institutions, introduces a framework called Mal‑ID (MAchine Learning for Immunological Diagnosis).... Read More