15 challenges at the intersection of biology & AI

A new Perspective in Cell, co-authored by HIP Co-Chief Science Officer John Tsang alongside leading researchers from Columbia, Stanford, and the Chan Zuckerberg Initiative, tackles one of the biggest open questions in biomedical AI: why hasn’t generative AI’s success in protein folding translated to predicting how cells and tissues actually behave? Drawing inspiration from Hilbert’s landmark…

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How do you measure an aging immune system? HIP Co-CSOs publish new framework.

A new Nature Medicine Perspective, “Immune Aging Biomarkers for Clinical Trials,” tackles a question at the heart of HIP’s mission: there’s still no agreed-upon way to measure immune aging. Co-authored by HIP Co-Chief Scientific Officers Shai Shen-Orr and John Tsang, alongside researchers from Stanford, Yale, UConn, University College London, the National Institute on Aging, and others, the…

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HIP Impact Session – Davos 2026

Open-science initiative makes the case for mapping the human immunome as the next frontier in medicine DAVOS, SWITZERLAND – January 21, 2026 — The Human Immunome Project (HIP) was invited to host a dedicated Impact Session at Frontiers Science House, the World Economic Forum’s science-focused venue on the Davos promenade, during its 56th Annual Meeting, January…

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Leading Immunologists Convene at Cold Spring Harbor to Decode the Human Immune System

Historic Banbury Conference Launches AI-powered Initiative to Decipher Human Immunity COLD SPRING HARBOR, NY – November 14, 2025 – The Human Immunome Project (HIP) convened the first meeting of their Scientific Partner Network, featuring the world’s leading systems immunology experts, at Cold Spring Harbor Laboratory’s prestigious Banbury Center, where the Human Genome Project strategy was incubated….

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Human Immunome Project Announces Scientific Partner Network 

Historic International Partnership to Develop the Infrastructure and Tools to Decipher the Human Immunome and Empower Global Immune-based Precision Medicine  NEW YORK, September 29, 2025 – The Human Immunome Project (HIP) – a global NGO using artificial intelligence and big data to unlock the secrets of the human immune system in health and disease – today…

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Human Immunome Project Congratulates Immunis on XPRIZE Healthspan Award, Announces Leadership Transition

New York — May 12, 2025 — The Human Immunome Project (HIP) congratulates Dr. Hans Keirstead and Immunis, Inc. for receiving a prestigious XPRIZE Healthspan Semi-finalist award and announces a strategic leadership transition at the conclusion of his two-year term as HIP CEO. Existing HIP Board Chair Jane Metcalfe takes on an Executive Chair role for the next…

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Advances in Systems Immunology and Machine Learning

The convergence of advanced immune monitoring technologies and artificial intelligence, particularly machine learning, is creating unprecedented opportunities to decode human immunity.  In a comprehensive review published in the Annual Review of Immunology in April 2025, “Systems Human Immunology and AI: Immune Setpoint and Immune Health,” Yona Lei and HIP Co-Chief Science Officer John Tsang review and provide perspectives…

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First Diagnostic Immunome Accurately Predicts Disease

“Disease diagnostics using machine learning of B cell and T cell receptor sequences”, published in Science on February 21, 2025, is a world-first demonstration of the scientific underpinnings of the Human Immunome Project. The study, led by Maxim Zaslavsky, Erin Craig, Anshul Kundaje, Scott Boyd and colleagues at Stanford and other institutions, introduces a framework called Mal‑ID (MAchine Learning for Immunological Diagnosis)….

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Human Immunome Project and Michelson Medical Research Foundation Award $150,000 Grants to Three Early-Career Scientists Advancing Immunology and Vaccines

Dr.  Omar Abudayyeh, Dr. Caleb Lareau, and Dr. Yuzhong Liu, to receive $150,000 grants for immunology and vaccine research. NEW YORK, February 19, 2025 — The Human Immunome Project (HIP) and Michelson Medical Research Foundation (MMRF) have awarded Dr. Omar Abudayyeh (Brigham and Women’s Hospital; Harvard Medical School), Dr. Caleb Lareau (Memorial Sloan Kettering Cancer…

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Danaher Subsidiaries Provide Support to the Human Immunome Project, Advancing Global Effort to Map and Model Immune System

NEW YORK, December 3, 2024 — Three subsidiaries of Danaher Corporation (“Danaher”), a leading global life sciences and diagnostics innovator, are supporting the nonprofit Human Immunome Project (HIP) with access to reagents, assays, and equipment. Danaher’s participation will help HIP to generate the world’s most comprehensive immunological dataset and provide a transformative new resource to the…

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